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Chapter 16 Pharmacology of Gastrointestinal drugs (1 of 80) Sample Questions

1. What is NOT a risk factor of gastroesophageal reflux disease (GERD)?
  1. A. Diabetes
  2. B. Crohn’s disease
  3. C. Scleroderma
  4. D. Obesity
  5. E. Asthma
Answer
Ans: B
Tips: GERD risk factors:
 Obesity, Pregnancy, Heavy meals, Hiatus hernia, Scelroderma, carbonated drinks and eating late at night, fatty foods.
 Chocolate, alcohol, caffeine, CCB, alpha and beta blockers, nitrates, BZDs decrease lower esophageal sphincter tone.
 Age > 65, stress
Crohn's disease is not typically considered a risk factor for GERD. Crohn's disease is a chronic inflammatory bowel disease that primarily affects the intestines, causing inflammation and ulceration. While it can lead to various gastrointestinal symptoms, it is not directly associated with an increased risk of developing GERD.
Diabetes, scleroderma, obesity, and asthma are known risk factors for GERD. Diabetes can affect the function of the lower esophageal sphincter (LES), contributing to acid reflux. Scleroderma can cause tightening and thickening of the esophageal tissues, leading to impaired LES function. Obesity increases abdominal pressure, which can push stomach contents into the esophagus. Asthma, especially when uncontrolled, can be associated with a higher risk of GERD due to increased intra-abdominal pressure and potential relaxation of the LES. Therefore, among the given options, Crohn's disease is the one that is not typically considered a risk factor for GERD.
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